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1x5d
From Proteopedia
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==The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6== | ==The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6== | ||
| - | <StructureSection load='1x5d' size='340' side='right'caption='[[1x5d | + | <StructureSection load='1x5d' size='340' side='right'caption='[[1x5d]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x5d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1x5d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5D FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5d OCA], [https://pdbe.org/1x5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5d RCSB], [https://www.ebi.ac.uk/pdbsum/1x5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5d TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5d OCA], [https://pdbe.org/1x5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5d RCSB], [https://www.ebi.ac.uk/pdbsum/1x5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5d TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PDIA6_HUMAN PDIA6_HUMAN] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.<ref>PMID:15466936</ref> <ref>PMID:12204115</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Inoue M]] | |
| - | [[Category: Inoue | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Koshiba S]] |
| - | [[Category: Koshiba | + | [[Category: Tochio N]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Tochio | + | |
| - | [[Category: Yokoyama | + | |
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Current revision
The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Tochio N | Yokoyama S
