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1x6g
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1x6g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x6g" /> '''Solution structures of the SH3 domain of hu...) |
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| - | [[Image:1x6g.gif|left|200px]]<br /> | ||
| - | <applet load="1x6g" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1x6g" /> | ||
| - | '''Solution structures of the SH3 domain of human megakaryocyte-associated tyrosine-protein kinase.'''<br /> | ||
| - | == | + | ==Solution structures of the SH3 domain of human megakaryocyte-associated tyrosine-protein kinase.== |
| - | + | <StructureSection load='1x6g' size='340' side='right'caption='[[1x6g]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1x6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6g OCA], [https://pdbe.org/1x6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6g RCSB], [https://www.ebi.ac.uk/pdbsum/1x6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6g ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6g TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MATK_HUMAN MATK_HUMAN] Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.<ref>PMID:9171348</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x6g_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x6g ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Inoue M]] | |
| - | [[Category: Inoue | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Koshiba S]] |
| - | [[Category: Koshiba | + | [[Category: Sato M]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Sato | + | |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structures of the SH3 domain of human megakaryocyte-associated tyrosine-protein kinase.
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Sato M | Yokoyama S
