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1x9z
From Proteopedia
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==Crystal structure of the MutL C-terminal domain== | ==Crystal structure of the MutL C-terminal domain== | ||
| - | <StructureSection load='1x9z' size='340' side='right' caption='[[1x9z]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='1x9z' size='340' side='right'caption='[[1x9z]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x9z]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1x9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X9Z FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9z OCA], [https://pdbe.org/1x9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x9z RCSB], [https://www.ebi.ac.uk/pdbsum/1x9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x9z ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MUTL_ECOLI MUTL_ECOLI] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/1x9z_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/1x9z_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1x9z" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1x9z" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[DNA mismatch repair protein 3D structures|DNA mismatch repair protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | [[Category: Ghirlando | + | [[Category: Large Structures]] |
| - | [[Category: Guarne | + | [[Category: Ghirlando R]] |
| - | [[Category: Hu | + | [[Category: Guarne A]] |
| - | [[Category: Miller | + | [[Category: Hu X]] |
| - | [[Category: Ramon-Maiques | + | [[Category: Miller JH]] |
| - | [[Category: Wolff | + | [[Category: Ramon-Maiques S]] |
| - | [[Category: Yang | + | [[Category: Wolff EM]] |
| - | + | [[Category: Yang W]] | |
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Current revision
Crystal structure of the MutL C-terminal domain
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Categories: Escherichia coli | Large Structures | Ghirlando R | Guarne A | Hu X | Miller JH | Ramon-Maiques S | Wolff EM | Yang W
