1dz1

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{{Seed}}
 
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[[Image:1dz1.png|left|200px]]
 
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==Mouse HP1 (M31) C terminal (shadow chromo) domain==
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The line below this paragraph, containing "STRUCTURE_1dz1", creates the "Structure Box" on the page.
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<StructureSection load='1dz1' size='340' side='right'caption='[[1dz1]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DZ1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dz1 OCA], [https://pdbe.org/1dz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1dz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dz1 ProSAT]</span></td></tr>
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{{STRUCTURE_1dz1| PDB=1dz1 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBX1_MOUSE CBX1_MOUSE] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/1dz1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dz1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The heterochromatin protein 1 (HP1) family of proteins is involved in gene silencing via the formation of heterochromatic structures. They are composed of two related domains: an N-terminal chromo domain and a C-terminal shadow chromo domain. Present results suggest that chromo domains may function as protein interaction motifs, bringing together different proteins in multi-protein complexes and locating them in heterochromatin. We have previously determined the structure of the chromo domain from the mouse HP1beta protein, MOD1. We show here that, in contrast to the chromo domain, the shadow chromo domain is a homodimer. The intact HP1beta protein is also dimeric, where the interaction is mediated by the shadow chromo domain, with the chromo domains moving independently of each other at the end of flexible linkers. Mapping studies, with fragments of the CAF1 and TIF1beta proteins, show that an intact, dimeric, shadow chromo domain structure is required for complex formation.
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===MOUSE HP1 (M31) C TERMINAL (SHADOW CHROMO) DOMAIN===
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The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer.,Brasher SV, Smith BO, Fogh RH, Nietlispach D, Thiru A, Nielsen PR, Broadhurst RW, Ball LJ, Murzina NV, Laue ED EMBO J. 2000 Apr 3;19(7):1587-97. PMID:10747027<ref>PMID:10747027</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10747027}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1dz1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10747027 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10747027}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1DZ1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZ1 OCA].
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==Reference==
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<ref group="xtra">PMID:10747027</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ball, L J.]]
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[[Category: Ball LJ]]
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[[Category: Brasher, S V.]]
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[[Category: Brasher SV]]
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[[Category: Broadhurst, R W.]]
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[[Category: Broadhurst RW]]
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[[Category: Fogh, R H.]]
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[[Category: Fogh RH]]
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[[Category: Laue, E D.]]
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[[Category: Laue ED]]
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[[Category: Murzina, N.]]
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[[Category: Murzina N]]
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[[Category: Nielsen, P R.]]
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[[Category: Nielsen PR]]
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[[Category: Nietlispach, D.]]
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[[Category: Nietlispach D]]
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[[Category: Smith, B O.]]
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[[Category: Smith BO]]
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[[Category: Thiru, A.]]
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[[Category: Thiru A]]
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[[Category: Chromatin structure]]
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[[Category: Chromo domain]]
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[[Category: Heterochromatin protein protein interaction]]
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[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:09:00 2009''
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Current revision

Mouse HP1 (M31) C terminal (shadow chromo) domain

PDB ID 1dz1

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