This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1e4u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:29, 15 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
==N-TERMINAL RING FINGER DOMAIN OF HUMAN NOT-4==
+
 
-
<StructureSection load='1e4u' size='340' side='right' caption='[[1e4u]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
+
==N-terminal RING finger domain of human NOT-4==
 +
<StructureSection load='1e4u' size='340' side='right'caption='[[1e4u]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1e4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E4U FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1e4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E4U FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e4u RCSB], [http://www.ebi.ac.uk/pdbsum/1e4u PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e4u OCA], [https://pdbe.org/1e4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e4u RCSB], [https://www.ebi.ac.uk/pdbsum/1e4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e4u ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CNOT4_HUMAN CNOT4_HUMAN] Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex.<ref>PMID:11823428</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/1e4u_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/1e4u_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e4u ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 24: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 1e4u" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Line 29: Line 34:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Albert, T K]]
+
[[Category: Large Structures]]
-
[[Category: Boelens, R]]
+
[[Category: Albert TK]]
-
[[Category: Hanzawa, H]]
+
[[Category: Boelens R]]
-
[[Category: Ruwe, M J.De]]
+
[[Category: De Ruwe MJ]]
-
[[Category: Timmers, H T]]
+
[[Category: Hanzawa H]]
-
[[Category: Vliet, P C.Van Der]]
+
[[Category: Timmers HT]]
-
[[Category: Gene regulation]]
+
[[Category: Van Der Vliet PC]]
-
[[Category: Transcriptional control]]
+

Current revision

N-terminal RING finger domain of human NOT-4

PDB ID 1e4u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e4u"
Personal tools