1gjs

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{{Seed}}
 
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[[Image:1gjs.png|left|200px]]
 
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<!--
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==Solution structure of the Albumin binding domain of Streptococcal Protein G==
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The line below this paragraph, containing "STRUCTURE_1gjs", creates the "Structure Box" on the page.
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<StructureSection load='1gjs' size='340' side='right'caption='[[1gjs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjs OCA], [https://pdbe.org/1gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjs RCSB], [https://www.ebi.ac.uk/pdbsum/1gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjs ProSAT]</span></td></tr>
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{{STRUCTURE_1gjs| PDB=1gjs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/1gjs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gjs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle similar to the albumin binding domain of protein PAB from Peptostreptococcus magnus. The two domains share 59% sequence identity, are thermally very stable, and bind to the same site on human serum albumin. The albumin binding site, the first determined for this structural motif known as the GA module, comprises residues spanning the first loop to the beginning of the third helix and includes the most conserved region of GA modules. The two GA modules have different affinities for albumin from different species, and their albumin binding patterns correspond directly to the host specificity of C/G streptococci and P. magnus, respectively. These studies of the evolution, structure, and binding properties of the GA module emphasize the power of bacterial adaptation and underline ecological and medical problems connected with the use of antibiotics.
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===SOLUTION STRUCTURE OF THE ALBUMIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G===
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Structure, specificity, and mode of interaction for bacterial albumin-binding modules.,Johansson MU, Frick IM, Nilsson H, Kraulis PJ, Hober S, Jonasson P, Linhult M, Nygren PA, Uhlen M, Bjorck L, Drakenberg T, Forsen S, Wikstrom M J Biol Chem. 2002 Mar 8;277(10):8114-20. Epub 2001 Dec 18. PMID:11751858<ref>PMID:11751858</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11751858}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gjs" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11751858 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_11751858}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1GJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJS OCA].
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[[Category: Streptococcus sp]]
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[[Category: Bjorck L]]
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==Reference==
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[[Category: Drakenberg T]]
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Structure, specificity, and mode of interaction for bacterial albumin-binding modules., Johansson MU, Frick IM, Nilsson H, Kraulis PJ, Hober S, Jonasson P, Linhult M, Nygren PA, Uhlen M, Bjorck L, Drakenberg T, Forsen S, Wikstrom M, J Biol Chem. 2002 Mar 8;277(10):8114-20. Epub 2001 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11751858 11751858]
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[[Category: Forsen S]]
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[[Category: Bacteria]]
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[[Category: Frick IM]]
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[[Category: Single protein]]
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[[Category: Hober S]]
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[[Category: Bjorck, L.]]
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[[Category: Johansson MU]]
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[[Category: Drakenbergforsen, S.]]
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[[Category: Jonasson P]]
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[[Category: Frick, I M.]]
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[[Category: Kraulis PJ]]
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[[Category: Hober, S.]]
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[[Category: Nilsson H]]
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[[Category: Johansson, M U.]]
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[[Category: Nygren AP]]
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[[Category: Jonasson, P.]]
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[[Category: Uhlen M]]
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[[Category: Kraulis, P J.]]
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[[Category: Wikstrom M]]
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[[Category: Nilsson, H.]]
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[[Category: Nygren, P A.]]
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[[Category: Uhlen, M.]]
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[[Category: Wikstrom, M.]]
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[[Category: Albumin binding]]
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[[Category: Bacterial surface protein]]
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[[Category: Protein g]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:24:11 2008''
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Current revision

Solution structure of the Albumin binding domain of Streptococcal Protein G

PDB ID 1gjs

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Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gjs"
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