1gl5

Structural highlights

Function

TEC_MOUSE Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82'. May also be involved in the regulation of osteoclast differentiation.^{[1] [2] [3] [4] [5] [6]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Tyrosine kinase 3D structures

References

1. ↑ Yang WC, Olive D. Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway. Eur J Immunol. 1999 Jun;29(6):1842-9. PMID:10382746 doi:<1842::AID-IMMU1842>3.0.CO;2-D 10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D
2. ↑ Garçon F, Ghiotto M, Gérard A, Yang WC, Olive D, Nunès JA. The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule. Eur J Immunol. 2004 Jul;34(7):1972-80. PMID:15214045 doi:10.1002/eji.200324777
3. ↑ Schmidt U, Abramova A, Boucheron N, Eckelhart E, Schebesta A, Bilic I, Kneidinger M, Unger B, Hammer M, Sibilia M, Valent P, Ellmeier W. The protein tyrosine kinase Tec regulates mast cell function. Eur J Immunol. 2009 Nov;39(11):3228-38. PMID:19688741 doi:10.1002/eji.200838839
4. ↑ Li F, Jiang Y, Zheng Q, Yang X, Wang S. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF. Biochem Biophys Res Commun. 2011 Jan 7;404(1):79-85. PMID:21094130 doi:10.1016/j.bbrc.2010.11.068
5. ↑ Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H. Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription. Blood. 1998 Mar 1;91(5):1496-507. PMID:9473212
6. ↑ Yang WC, Ghiotto M, Barbarat B, Olive D. The role of Tec protein-tyrosine kinase in T cell signaling. J Biol Chem. 1999 Jan 8;274(2):607-17. PMID:9872994 doi:10.1074/jbc.274.2.607
7. ↑ Pursglove SE, Mulhern TD, Mackay JP, Hinds MG, Booker GW. The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain. J Biol Chem. 2002 Jan 4;277(1):755-62. Epub 2001 Oct 29. PMID:11684687 doi:10.1074/jbc.M108318200