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1gm1

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==SECOND PDZ DOMAIN (PDZ2) OF PTP-BL==
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<StructureSection load='1gm1' size='340' side='right' caption='[[1gm1]], [[NMR_Ensembles_of_Models | 35 NMR models]]' scene=''>
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==Second PDZ Domain (PDZ2) of PTP-BL==
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<StructureSection load='1gm1' size='340' side='right'caption='[[1gm1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gm1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GM1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GM1 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gm1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gm1 RCSB], [http://www.ebi.ac.uk/pdbsum/1gm1 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gm1 OCA], [https://pdbe.org/1gm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gm1 RCSB], [https://www.ebi.ac.uk/pdbsum/1gm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gm1 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN13_MOUSE PTN13_MOUSE] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gm1_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gm1_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gm1 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1gm1" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Aelen J]]
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[[Category: Aelen, J]]
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[[Category: Hendriks W]]
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[[Category: Hendriks, W]]
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[[Category: Schepens J]]
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[[Category: Schepens, J]]
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[[Category: Tessari M]]
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[[Category: Tessari, M]]
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[[Category: Vuister GW]]
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[[Category: Vuister, G W]]
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[[Category: Walma T]]
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[[Category: Walma, T]]
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[[Category: Cytoskeleton]]
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[[Category: Fas interaction]]
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[[Category: Hydrolase]]
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[[Category: Lim interaction]]
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[[Category: Pdz]]
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[[Category: Ptp-bl]]
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[[Category: Structural protein]]
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Current revision

Second PDZ Domain (PDZ2) of PTP-BL

PDB ID 1gm1

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OCA

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