1h3z

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(New page: 200px<br /><applet load="1h3z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h3z" /> '''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCH...)
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[[Image:1h3z.jpg|left|200px]]<br /><applet load="1h3z" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1h3z" />
 
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'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''<br />
 
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==Overview==
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==Solution structure of a PWWP domain from Schizosaccharomyces Pombe==
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The PWWP domain is a ubiquitous eukaryotic protein module characterised by, a region of sequence similarity of approximately 80 amino acids containing, a highly conserved PWWP motif. It is frequently found in proteins, associated with chromatin. We have determined the structure of a PWWP, domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The, structure is composed of a five stranded beta barrel followed by two alpha, helices. Comparison to the recently reported structure of a homologous, domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial, differences both in the C-terminal helical region and in the PWWP motif.
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<StructureSection load='1h3z' size='340' side='right'caption='[[1h3z]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1h3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H3Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3z OCA], [https://pdbe.org/1h3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h3z RCSB], [https://www.ebi.ac.uk/pdbsum/1h3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDP2_SCHPO PDP2_SCHPO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h3z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h3z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
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==About this Structure==
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Structural variation in PWWP domains.,Slater LM, Allen MD, Bycroft M J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472<ref>PMID:12842472</ref>
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1H3Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12842472 12842472]
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</div>
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<div class="pdbe-citations 1h3z" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
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[[Category: Single protein]]
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[[Category: Allen MD]]
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[[Category: Allen, M.D.]]
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[[Category: Bycroft M]]
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[[Category: Bycroft, M.]]
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[[Category: Slater LM]]
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[[Category: Slater, L.M.]]
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[[Category: beta-barrel]]
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[[Category: chromatin]]
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[[Category: pwwp]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:24:48 2007''
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Current revision

Solution structure of a PWWP domain from Schizosaccharomyces Pombe

PDB ID 1h3z

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