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1ql5

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{{Seed}}
 
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[[Image:1ql5.png|left|200px]]
 
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==DNA DECAMER DUPLEX CONTAINING T5-T6 PHOTOADDUCT==
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The line below this paragraph, containing "STRUCTURE_1ql5", creates the "Structure Box" on the page.
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<StructureSection load='1ql5' size='340' side='right'caption='[[1ql5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ql5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QL5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PBT:[3-HYDROXY-5-(5-METHYL-2,4-DIOXOTETRAHYDRO-1(2H)-PYRIMIDINYL)TETRAHYDRO-2-FURANYL]METHYL+DIHYDROGEN+PHOSPHATE'>PBT</scene></td></tr>
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{{STRUCTURE_1ql5| PDB=1ql5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ql5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ql5 OCA], [https://pdbe.org/1ql5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ql5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ql5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ql5 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cis - syn dimer is the major DNA photoproduct produced by UV irradiation. In order to determine the origin of the mutagenic property of the cis - syn dimer, we used NMR restraints and molecular dynamics to determine the solution structure of a DNA decamer duplex containing a wobble pair between the 3'-T of the cis - syn dimer and the opposite T residue (CS/TA duplex). The solution structure of the CS/TA duplex revealed that the 3'-T x T base pair of the cis - syn dimer had base pair geometry that was significantly different from the canonical Watson-Crick base pair and caused destabilization and conformational distortion of its 3'-region. However, a 3'-T x A base pair at the cis - syn dimer within this related DNA decamer maintains the normal Watson-Crick base pair geometry and causes little distortion in the conformation of its 3'-side. Our results show that in spite of its stable hydrogen bonding, the insertion of a T residue opposite the 3'-T of the cis - syn dimer is inhibited by structural distortion caused by the 3'-T x T base pair. This may explain why the frequency of the 3'-T--&gt;A transversion, which is the major mutation produced by the cis - syn dimer, is only 4%.
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===DNA DECAMER DUPLEX CONTAINING T5-T6 PHOTOADDUCT===
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Solution structure of the DNA decamer duplex containing a 3'-T x T basepair of the cis-syn cyclobutane pyrimidine dimer: implication for the mutagenic property of the cis-syn dimer.,Lee JH, Choi YJ, Choi BS Nucleic Acids Res. 2000 Apr 15;28(8):1794-801. PMID:10734199<ref>PMID:10734199</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10734199}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ql5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10734199 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10734199}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL5 OCA].
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[[Category: Choi B-S]]
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[[Category: Hwang G-S]]
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==Reference==
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[[Category: Lee J-H]]
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Solution structure of the DNA decamer duplex containing a 3'-T x T basepair of the cis-syn cyclobutane pyrimidine dimer: implication for the mutagenic property of the cis-syn dimer., Lee JH, Choi YJ, Choi BS, Nucleic Acids Res. 2000 Apr 15;28(8):1794-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10734199 10734199]
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[[Category: Choi, B S.]]
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[[Category: Hwang, G S.]]
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[[Category: Lee, J H.]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: Dna photoproduct]]
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[[Category: Mutagenesis]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:52:52 2008''
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Current revision

DNA DECAMER DUPLEX CONTAINING T5-T6 PHOTOADDUCT

PDB ID 1ql5

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