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2kw6

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==Solution NMR Structure of Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1; oral cancer suppressor Deleted in oral cancer 1, DOC-1) from H.sapiens, Northeast Structural Genomics Consortium Target Target HR3057H==
==Solution NMR Structure of Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1; oral cancer suppressor Deleted in oral cancer 1, DOC-1) from H.sapiens, Northeast Structural Genomics Consortium Target Target HR3057H==
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<StructureSection load='2kw6' size='340' side='right' caption='[[2kw6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kw6' size='340' side='right'caption='[[2kw6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KW6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kw6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KW6 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2AP1, CDKAP1, DOC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kw6 RCSB], [http://www.ebi.ac.uk/pdbsum/2kw6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw6 OCA], [https://pdbe.org/2kw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kw6 RCSB], [https://www.ebi.ac.uk/pdbsum/2kw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kw6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CDKA1_HUMAN CDKA1_HUMAN]] specific inhibitor of the cell-cycle kinase CDK2 (By similarity).
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[https://www.uniprot.org/uniprot/CDKA1_HUMAN CDKA1_HUMAN] specific inhibitor of the cell-cycle kinase CDK2 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/2kw6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/2kw6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kw6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2kw6" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B]]
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[[Category: Large Structures]]
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[[Category: Aramini, J M]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti, C T]]
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[[Category: Aramini JM]]
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[[Category: Ertekin, A]]
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[[Category: Ciccosanti CT]]
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[[Category: Everett, J K]]
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[[Category: Ertekin A]]
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[[Category: Jiang, M]]
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[[Category: Everett JK]]
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[[Category: Lee, A B]]
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[[Category: Jiang M]]
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[[Category: Montelione, G T]]
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[[Category: Lee AB]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Prestegard, J H]]
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[[Category: Prestegard JH]]
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[[Category: Rossi, P]]
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[[Category: Rossi P]]
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[[Category: Rost, B]]
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[[Category: Rost B]]
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[[Category: Swapna, G V.T]]
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[[Category: Swapna GVT]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: Cancer suppressor]]
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[[Category: Cell cycle]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Solution NMR Structure of Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1; oral cancer suppressor Deleted in oral cancer 1, DOC-1) from H.sapiens, Northeast Structural Genomics Consortium Target Target HR3057H

PDB ID 2kw6

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