This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2l76
From Proteopedia
(Difference between revisions)
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto== | ==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto== | ||
| - | <StructureSection load='2l76' size='340' side='right' caption='[[2l76 | + | <StructureSection load='2l76' size='340' side='right'caption='[[2l76]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | [[2l76]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L76 FirstGlance]. <br> |
| - | <b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [https://pdbe.org/2l76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [https://www.ebi.ac.uk/pdbsum/2l76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l76 ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Doherty | + | [[Category: Dhe-Paganon S]] |
| - | [[Category: Houliston | + | [[Category: Doherty R]] |
| - | + | [[Category: Houliston S]] | |
| - | + | [[Category: Semesi A]] | |
| - | [[Category: Semesi | + | [[Category: Wu B]] |
| - | [[Category: Wu | + | [[Category: Yee A]] |
| - | [[Category: Yee | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Dhe-Paganon S | Doherty R | Houliston S | Semesi A | Wu B | Yee A
