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2l8u

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[[Image:2l8u.jpg|left|200px]]
 
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==NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with one hydrogen bond pair==
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The line below this paragraph, containing "STRUCTURE_2l8u", creates the "Structure Box" on the page.
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<StructureSection load='2l8u' size='340' side='right'caption='[[2l8u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8u OCA], [https://pdbe.org/2l8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8u RCSB], [https://www.ebi.ac.uk/pdbsum/2l8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8u ProSAT]</span></td></tr>
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{{STRUCTURE_2l8u| PDB=2l8u | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR structure of an RNA with a copy of the 5'CUG/3'GUC motif found in the triplet repeating disorder myotonic dystrophy type 1 (DM1) is disclosed. The lowest energy conformation of the UU pair is a single-hydrogen bond structure; however, the UU protons undergo exchange indicating structural dynamics. Molecular dynamics simulations show that the single hydrogen bond structure is the most populated one but the UU pair interconverts among zero, one, and two hydrogen bond pairs. These studies have implications for the recognition of the DM1 RNA by small molecules and proteins.
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===NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with one hydrogen bond pair===
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NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)(2) Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1.,Parkesh R, Fountain M, Disney MD Biochemistry. 2011 Feb 8;50(5):599-601. Epub 2011 Jan 13. PMID:21204525<ref>PMID:21204525</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l8u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21204525 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21204525}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2l8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8U OCA].
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[[Category: Synthetic construct]]
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[[Category: Disney MD]]
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==Reference==
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[[Category: Fountain MA]]
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<ref group="xtra">PMID:21204525</ref><references group="xtra"/>
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[[Category: Parkesh R]]
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[[Category: Disney, M D.]]
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[[Category: Fountain, M A.]]
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[[Category: Parkesh, R.]]
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Current revision

NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with one hydrogen bond pair

PDB ID 2l8u

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