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2lkc

From Proteopedia

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[[Image:2lkc.jpg|left|200px]]
 
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==Free B.st IF2-G2==
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The line below this paragraph, containing "STRUCTURE_2lkc", creates the "Structure Box" on the page.
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<StructureSection load='2lkc' size='340' side='right'caption='[[2lkc]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkc OCA], [https://pdbe.org/2lkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkc RCSB], [https://www.ebi.ac.uk/pdbsum/2lkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkc ProSAT]</span></td></tr>
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{{STRUCTURE_2lkc| PDB=2lkc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF2_GEOSE IF2_GEOSE] One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial translation initiation factor IF2 promotes ribosomal subunit association, recruitment, and binding of fMet-tRNA to the ribosomal P-site and initiation dipeptide formation. Here, we present the solution structures of GDP-bound and apo-IF2-G2 of Bacillus stearothermophilus and provide evidence that this isolated domain binds the 50 S ribosomal subunit and hydrolyzes GTP. Differences between the free and GDP-bound structures of IF2-G2 suggest that domain reorganization within the G2-G3-C1 regions underlies the different structural requirements of IF2 during the initiation process. However, these structural signals are unlikely forwarded from IF2-G2 to the C-terminal fMet-tRNA binding domain (IF2-C2) because the connected IF2-C1 and IF2-C2 modules show completely independent mobility, indicating that the bacterial interdomain connector lacks the rigidity that was found in the archaeal IF2 homolog aIF5B.
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===Free B.st IF2-G2===
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Structural Dynamics of Bacterial Translation Initiation Factor IF2.,Wienk H, Tishchenko E, Belardinelli R, Tomaselli S, Dongre R, Spurio R, Folkers GE, Gualerzi CO, Boelens R J Biol Chem. 2012 Mar 30;287(14):10922-32. Epub 2012 Feb 3. PMID:22308033<ref>PMID:22308033</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2lkc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKC OCA].
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<div class="pdbe-citations 2lkc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Belardinelli, R.]]
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[[Category: Large Structures]]
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[[Category: Boelens, R.]]
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[[Category: Belardinelli R]]
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[[Category: Dongre, R.]]
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[[Category: Boelens R]]
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[[Category: Folkers, G E.]]
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[[Category: Dongre R]]
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[[Category: Gualerzi, C O.]]
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[[Category: Folkers GE]]
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[[Category: Spurio, R.]]
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[[Category: Gualerzi CO]]
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[[Category: Tishchenko, E.]]
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[[Category: Spurio R]]
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[[Category: Tomaselli, S.]]
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[[Category: Tishchenko E]]
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[[Category: Wienk, H.]]
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[[Category: Tomaselli S]]
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[[Category: Translation]]
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[[Category: Wienk H]]

Current revision

Free B.st IF2-G2

PDB ID 2lkc

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