2lnb

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'''Unreleased structure'''
 
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The entry 2lnb is ON HOLD
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==Solution NMR structure of N-terminal domain (6-74) of human ZBP1 protein, Northeast Structural Genomics Consortium Target HR8174A.==
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<StructureSection load='2lnb' size='340' side='right'caption='[[2lnb]]' scene=''>
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Authors: Yang, Y., Ramelot, T.A., Hamilton, K., Kohan, E., Wang, D., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNB FirstGlance]. <br>
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Description: Solution NMR structure of N-terminal domain (6-74) of human ZBP1 protein, Northeast Structural Genomics Consortium Target HR8174A. (CASP Target)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnb OCA], [https://pdbe.org/2lnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnb RCSB], [https://www.ebi.ac.uk/pdbsum/2lnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Everett JK]]
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[[Category: Hamilton K]]
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[[Category: Kennedy MA]]
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[[Category: Kohan E]]
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[[Category: Montelione GT]]
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[[Category: Ramelot TA]]
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[[Category: Wang D]]
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[[Category: Xiao R]]
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[[Category: Yang Y]]

Current revision

Solution NMR structure of N-terminal domain (6-74) of human ZBP1 protein, Northeast Structural Genomics Consortium Target HR8174A.

PDB ID 2lnb

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