2lnb

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[[Image:2lnb.jpg|left|200px]]
 
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==Solution NMR structure of N-terminal domain (6-74) of human ZBP1 protein, Northeast Structural Genomics Consortium Target HR8174A.==
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The line below this paragraph, containing "STRUCTURE_2lnb", creates the "Structure Box" on the page.
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<StructureSection load='2lnb' size='340' side='right'caption='[[2lnb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnb OCA], [https://pdbe.org/2lnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnb RCSB], [https://www.ebi.ac.uk/pdbsum/2lnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnb ProSAT]</span></td></tr>
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{{STRUCTURE_2lnb| PDB=2lnb | SCENE= }}
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</table>
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== Function ==
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===Solution NMR structure of N-terminal domain (6-74) of human ZBP1 protein, Northeast Structural Genomics Consortium Target HR8174A.===
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[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNB OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Everett, J K.]]
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[[Category: Acton TB]]
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[[Category: Hamilton, K.]]
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[[Category: Everett JK]]
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[[Category: Kennedy, M A.]]
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[[Category: Hamilton K]]
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[[Category: Kohan, E.]]
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[[Category: Kennedy MA]]
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[[Category: Montelione, G T.]]
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[[Category: Kohan E]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Ramelot, T A.]]
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[[Category: Ramelot TA]]
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[[Category: Wang, D.]]
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[[Category: Wang D]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Yang, Y.]]
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[[Category: Yang Y]]
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[[Category: Immune system]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Solution NMR structure of N-terminal domain (6-74) of human ZBP1 protein, Northeast Structural Genomics Consortium Target HR8174A.

PDB ID 2lnb

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