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2lpx

From Proteopedia

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[[Image:2lpx.jpg|left|200px]]
 
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==Solution Structure of Strawberry Allergen Fra a 1e==
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The line below this paragraph, containing "STRUCTURE_2lpx", creates the "Structure Box" on the page.
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<StructureSection load='2lpx' size='340' side='right'caption='[[2lpx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lpx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fragaria_x_ananassa Fragaria x ananassa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpx OCA], [https://pdbe.org/2lpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpx RCSB], [https://www.ebi.ac.uk/pdbsum/2lpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpx ProSAT]</span></td></tr>
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{{STRUCTURE_2lpx| PDB=2lpx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FRA1E_FRAAN FRA1E_FRAAN] Involved in the control of flavonoid biosynthesis in fruits, probably by binding directly to natural flavonoids (PubMed:19969523). Binds the natural flavonoid quercetin-3-O-glucuronide with affinities in the low micromolar range (PubMed:24133217).<ref>PMID:19969523</ref> <ref>PMID:24133217</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The PR10 family protein Fra a 1E from strawberry (Fragaria x ananassa) is down-regulated in white strawberry mutants, and transient RNAi (RNA interference)-mediated silencing experiments confirmed that Fra a 1 is involved in fruit pigment synthesis. In the present study, we determined the solution structure of Fra a 1E. The protein fold is identical with that of other members of the PR10 protein family and consists of a seven-stranded antiparallel beta-sheet, two short V-shaped alpha-helices and a long C-terminal alpha-helix that encompass a hydrophobic pocket. Whereas Fra a 1E contains the glycine-rich loop that is highly conserved throughout the protein family, the volume of the hydrophobic pocket and the size of its entrance are much larger than expected. The three-dimensional structure may shed some light on its physiological function and may help to further understand the role of PR10 proteins in plants.
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===Solution Structure of Strawberry Allergen Fra a 1e===
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Solution structure of the strawberry allergen Fra a 1.,Seutter von Loetzen C, Schweimer K, Schwab W, Rosch P, Hartl-Spiegelhauer O Biosci Rep. 2012 Dec 1;32(6):567-75. doi: 10.1042/BSR20120058. PMID:22913709<ref>PMID:22913709</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2lpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fragaria_x_ananassa Fragaria x ananassa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPX OCA].
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<div class="pdbe-citations 2lpx" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Fragaria x ananassa]]
[[Category: Fragaria x ananassa]]
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[[Category: Hartl-Spiegelhauer, O.]]
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[[Category: Large Structures]]
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[[Category: Loetzen, C Seutter von.]]
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[[Category: Hartl-Spiegelhauer O]]
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[[Category: Roesch, P.]]
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[[Category: Roesch P]]
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[[Category: Schwab, W.]]
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[[Category: Schwab W]]
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[[Category: Schweimer, K.]]
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[[Category: Schweimer K]]
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[[Category: Bet v 1 homologous protein]]
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[[Category: Seutter von Loetzen C]]
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[[Category: Unknown function]]
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Current revision

Solution Structure of Strawberry Allergen Fra a 1e

PDB ID 2lpx

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