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2m4h
From Proteopedia
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==Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein== | ==Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein== | ||
| - | <StructureSection load='2m4h' size='340' side='right' caption='[[2m4h | + | <StructureSection load='2m4h' size='340' side='right'caption='[[2m4h]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2m4h]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2m4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_calicivirus_strain_F9 Feline calicivirus strain F9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M4H FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m4h OCA], [https://pdbe.org/2m4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m4h RCSB], [https://www.ebi.ac.uk/pdbsum/2m4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m4h ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/POLG_FCVF9 POLG_FCVF9] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity). Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2m4h" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Feline calicivirus strain F9]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Birtley JR]] |
| - | [[Category: | + | [[Category: Curry S]] |
| - | [[Category: | + | [[Category: Kwok RN]] |
| - | [[Category: | + | [[Category: Leen EN]] |
| - | [[Category: | + | [[Category: Marchant J]] |
| - | + | [[Category: Matthews S]] | |
| - | [[Category: | + | [[Category: Prater SN]] |
| - | [[Category: | + | [[Category: Simpson PJ]] |
| - | [[Category: | + | |
Current revision
Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein
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