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2m52
From Proteopedia
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| - | {{STRUCTURE_2m52| PDB=2m52 | SCENE= }} | ||
| - | ===NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2=== | ||
| - | == | + | ==NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2== |
| - | [[2m52]] is a 1 chain structure with sequence from [ | + | <StructureSection load='2m52' size='340' side='right'caption='[[2m52]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2m52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M52 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m52 OCA], [https://pdbe.org/2m52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m52 RCSB], [https://www.ebi.ac.uk/pdbsum/2m52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m52 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/U2AF2_MOUSE U2AF2_MOUSE] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Dutta | + | [[Category: Dutta SK]] |
| - | [[Category: Geralt | + | [[Category: Geralt M]] |
| - | + | [[Category: Serrano P]] | |
| - | [[Category: Serrano | + | [[Category: Wuthrich K]] |
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| - | [[Category: Wuthrich | + | |
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Current revision
NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
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