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2m64
From Proteopedia
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==1H, 13C and 15N Chemical Shift Assignments for Phl p 5a== | ==1H, 13C and 15N Chemical Shift Assignments for Phl p 5a== | ||
| - | <StructureSection load='2m64' size='340' side='right'caption='[[2m64 | + | <StructureSection load='2m64' size='340' side='right'caption='[[2m64]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2m64]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2m64]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M64 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m64 OCA], [https://pdbe.org/2m64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m64 RCSB], [https://www.ebi.ac.uk/pdbsum/2m64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m64 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m64 OCA], [https://pdbe.org/2m64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m64 RCSB], [https://www.ebi.ac.uk/pdbsum/2m64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m64 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MPAP5_PHLPR MPAP5_PHLPR] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These findings may also form a basis for specific immunotherapy strategies. | ||
| + | |||
| + | Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.,Gobl C, Focke-Tejkl M, Najafi N, Schrank E, Madl T, Kosol S, Madritsch C, Dorofeeva Y, Flicker S, Thalhamer J, Valenta R, Zangger K, Tjandra N J Allergy Clin Immunol. 2017 Oct;140(4):1187-1191. doi: , 10.1016/j.jaci.2017.05.005. Epub 2017 May 19. PMID:28532654<ref>PMID:28532654</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2m64" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Common timothy]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Flicker | + | [[Category: Phleum pratense]] |
| - | [[Category: Focke | + | [[Category: Flicker S]] |
| - | [[Category: Goebl | + | [[Category: Focke M]] |
| - | [[Category: Kosol | + | [[Category: Goebl C]] |
| - | [[Category: Madl | + | [[Category: Kosol S]] |
| - | [[Category: Madritsch | + | [[Category: Madl T]] |
| - | [[Category: Schrank | + | [[Category: Madritsch C]] |
| - | [[Category: Tjandra | + | [[Category: Schrank E]] |
| - | [[Category: Valenta | + | [[Category: Tjandra N]] |
| - | [[Category: Zangger | + | [[Category: Valenta R]] |
| - | + | [[Category: Zangger K]] | |
Current revision
1H, 13C and 15N Chemical Shift Assignments for Phl p 5a
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Categories: Large Structures | Phleum pratense | Flicker S | Focke M | Goebl C | Kosol S | Madl T | Madritsch C | Schrank E | Tjandra N | Valenta R | Zangger K
