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2m8d

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==Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'==
==Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'==
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<StructureSection load='2m8d' size='340' side='right'caption='[[2m8d]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
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<StructureSection load='2m8d' size='340' side='right'caption='[[2m8d]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M8D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M8D FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRSF1, ASF, SF2, SF2P33, SFRS1, OK/SW-cl.3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8d OCA], [https://pdbe.org/2m8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m8d RCSB], [https://www.ebi.ac.uk/pdbsum/2m8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m8d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8d OCA], [https://pdbe.org/2m8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m8d RCSB], [https://www.ebi.ac.uk/pdbsum/2m8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m8d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN]] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>
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[https://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allain, F H.T]]
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[[Category: Allain FHT]]
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[[Category: Anczukow, O]]
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[[Category: Anczukow O]]
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[[Category: Clery, A]]
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[[Category: Clery A]]
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[[Category: Corrionero, A]]
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[[Category: Corrionero A]]
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[[Category: Daubner, G]]
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[[Category: Daubner G]]
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[[Category: Krainer, A R]]
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[[Category: Krainer AR]]
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[[Category: Moursy, A]]
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[[Category: Moursy A]]
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[[Category: Sinha, R]]
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[[Category: Sinha R]]
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[[Category: Valcarcel, J]]
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[[Category: Valcarcel J]]
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[[Category: Pseudo-rrm]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Rrm]]
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[[Category: Sr protein]]
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Current revision

Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'

PDB ID 2m8d

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