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2m9a
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2m9a is ON HOLD Authors: Pederson, K., Shastry, R., Kohan, E., Janjua, H., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Prestegard, J.H.,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A== | |
| + | <StructureSection load='2m9a' size='340' side='right'caption='[[2m9a]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2m9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9A FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9a OCA], [https://pdbe.org/2m9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9a RCSB], [https://www.ebi.ac.uk/pdbsum/2m9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Acton TB]] | ||
| + | [[Category: Everett JK]] | ||
| + | [[Category: Janjua H]] | ||
| + | [[Category: Kohan E]] | ||
| + | [[Category: Montelione GT]] | ||
| + | [[Category: Pederson K]] | ||
| + | [[Category: Prestegard JH]] | ||
| + | [[Category: Shastry R]] | ||
| + | [[Category: Xiao R]] | ||
Current revision
Solution NMR Structure of E3 ubiquitin-protein ligase ZFP91 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7784A
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Categories: Homo sapiens | Large Structures | Acton TB | Everett JK | Janjua H | Kohan E | Montelione GT | Pederson K | Prestegard JH | Shastry R | Xiao R
