This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ma5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:03, 15 May 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Solution NMR structure of PHD type Zinc finger domain of Lysine-specific demethylase 5B (PLU-1/JARID1B) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7375C==
==Solution NMR structure of PHD type Zinc finger domain of Lysine-specific demethylase 5B (PLU-1/JARID1B) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7375C==
-
<StructureSection load='2ma5' size='340' side='right' caption='[[2ma5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2ma5' size='340' side='right'caption='[[2ma5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2ma5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MA5 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2ma5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA5 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JARID1B, KDM5B, PLU1, RBBP2H1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ma5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ma5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ma5 PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma5 OCA], [https://pdbe.org/2ma5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma5 ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
 +
 +
==See Also==
 +
*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Acton, T B]]
+
[[Category: Large Structures]]
-
[[Category: Cort, J R]]
+
[[Category: Acton TB]]
-
[[Category: Everett, J K]]
+
[[Category: Cort JR]]
-
[[Category: Hassan, F]]
+
[[Category: Everett JK]]
-
[[Category: Janjua, H]]
+
[[Category: Hassan F]]
-
[[Category: Kennedy, M A]]
+
[[Category: Janjua H]]
-
[[Category: Kohan, E]]
+
[[Category: Kennedy MA]]
-
[[Category: Lee, D]]
+
[[Category: Kohan E]]
-
[[Category: Montelione, G T]]
+
[[Category: Lee D]]
-
[[Category: Structural genomic]]
+
[[Category: Montelione GT]]
-
[[Category: Ramelot, T A]]
+
[[Category: Ramelot TA]]
-
[[Category: Xiao, R]]
+
[[Category: Xiao R]]
-
[[Category: Yang, Y]]
+
[[Category: Yang Y]]
-
[[Category: Nesg]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Phd]]
+
-
[[Category: PSI, Protein structure initiative]]
+
-
[[Category: Psi-biology]]
+
-
[[Category: Zinc binding protein]]
+

Current revision

Solution NMR structure of PHD type Zinc finger domain of Lysine-specific demethylase 5B (PLU-1/JARID1B) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7375C

PDB ID 2ma5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ma5"
Personal tools