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2n00

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==NMR Solution structure of AIM2 PYD from Mus musculus==
==NMR Solution structure of AIM2 PYD from Mus musculus==
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<StructureSection load='2n00' size='340' side='right' caption='[[2n00]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n00' size='340' side='right'caption='[[2n00]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n00]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N00 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n00]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N00 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aim2, Gm1313, Ifi210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n00 OCA], [http://pdbe.org/2n00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n00 RCSB], [http://www.ebi.ac.uk/pdbsum/2n00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n00 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n00 OCA], [https://pdbe.org/2n00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n00 RCSB], [https://www.ebi.ac.uk/pdbsum/2n00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n00 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref>
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[https://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Hou, X]]
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[[Category: Mus musculus]]
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[[Category: Niu, X]]
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[[Category: Hou X]]
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[[Category: Aim2]]
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[[Category: Niu X]]
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[[Category: Dna binding protein]]
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[[Category: Pyd]]
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Current revision

NMR Solution structure of AIM2 PYD from Mus musculus

PDB ID 2n00

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