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2n4y

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'''Unreleased structure'''
 
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The entry 2n4y is ON HOLD until Paper Publication
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==Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome==
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<StructureSection load='2n4y' size='340' side='right'caption='[[2n4y]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4y OCA], [https://pdbe.org/2n4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4y RCSB], [https://www.ebi.ac.uk/pdbsum/2n4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4y ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection. The guanine-rich U3 region within the LTR promoter, previously shown to form G-quadruplex structures, represents an attractive target to inhibit HIV transcription and replication. In this work, we report the structure of a biologically relevant G-quadruplex within the LTR promoter region of HIV-1. The guanine-rich sequence designated LTR-IV forms a well-defined structure in physiological cationic solution. The nuclear magnetic resonance (NMR) structure of this sequence reveals a parallel-stranded G-quadruplex containing a single-nucleotide thymine bulge, which participates in a conserved stacking interaction with a neighboring single-nucleotide adenine loop. Transcription analysis in a HIV-1 replication competent cell indicates that the LTR-IV region may act as a modulator of G-quadruplex formation in the LTR promoter. Consequently, the LTR-IV G-quadruplex structure presented within this work could represent a valuable target for the design of HIV therapeutics.
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Authors: DeNicola, B., Lech, C.J., Regmi, S., Heddi, B., Richter, S., Phan, A.T.
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Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome.,De Nicola B, Lech CJ, Heddi B, Regmi S, Frasson I, Perrone R, Richter SN, Phan AT Nucleic Acids Res. 2016 Jun 13. pii: gkw432. PMID:27298260<ref>PMID:27298260</ref>
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Description: Structure of a G-quadruplex in the Long Terminal Repeat of the proviral HIV-1 genome
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Heddi, B]]
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<div class="pdbe-citations 2n4y" style="background-color:#fffaf0;"></div>
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[[Category: Regmi, S]]
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== References ==
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[[Category: Denicola, B]]
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<references/>
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[[Category: Phan, A.T]]
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__TOC__
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[[Category: Richter, S]]
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</StructureSection>
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[[Category: Lech, C.J]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: DeNicola B]]
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[[Category: Frasson I]]
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[[Category: Heddi B]]
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[[Category: Lech CJ]]
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[[Category: Perrone R]]
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[[Category: Phan AT]]
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[[Category: Regmi S]]
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[[Category: Richter SN]]

Current revision

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

PDB ID 2n4y

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