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1xoy

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(New page: 200px<br /><applet load="1xoy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xoy" /> '''Solution structure of At3g04780.1, an Arabid...)
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[[Image:1xoy.gif|left|200px]]<br /><applet load="1xoy" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xoy" />
 
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'''Solution structure of At3g04780.1, an Arabidopsis ortholog of the C-terminal domain of human thioredoxin-like protein'''<br />
 
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==Overview==
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==Solution structure of At3g04780.1, an Arabidopsis ortholog of the C-terminal domain of human thioredoxin-like protein==
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The structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of, the C-terminal domain of human thioredoxin-like protein, was determined by, NMR spectroscopy. The structure is dominated by a beta-barrel sandwich. A, two-stranded anti-parallel beta-sheet, which seals off one end of the, beta-barrel, is flanked by two flexible loops rich in acidic amino acids., Although this fold often provides a ligand binding site, the structure did, not reveal an appreciable cavity inside the beta-barrel. The, three-dimensional structure of At3g04780.1-des15 provides an entry point, for understanding its functional role and those of its mammalian homologs.
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<StructureSection load='1xoy' size='340' side='right'caption='[[1xoy]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xoy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XOY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xoy OCA], [https://pdbe.org/1xoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xoy RCSB], [https://www.ebi.ac.uk/pdbsum/1xoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xoy ProSAT], [https://www.topsan.org/Proteins/CESG/1xoy TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PITH1_ARATH PITH1_ARATH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xo/1xoy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xoy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein, was determined by NMR spectroscopy. The structure is dominated by a beta-barrel sandwich. A two-stranded anti-parallel beta-sheet, which seals off one end of the beta-barrel, is flanked by two flexible loops rich in acidic amino acids. Although this fold often provides a ligand binding site, the structure did not reveal an appreciable cavity inside the beta-barrel. The three-dimensional structure of At3g04780.1-des15 provides an entry point for understanding its functional role and those of its mammalian homologs.
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==About this Structure==
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Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein.,Song J, Tyler RC, Wrobel RL, Frederick RO, Vojtek FC, Jeon WB, Lee MS, Markley JL Protein Sci. 2005 Apr;14(4):1059-63. Epub 2005 Mar 1. PMID:15741346<ref>PMID:15741346</ref>
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1XOY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XOY OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein., Song J, Tyler RC, Wrobel RL, Frederick RO, Vojtek FC, Jeon WB, Lee MS, Markley JL, Protein Sci. 2005 Apr;14(4):1059-63. Epub 2005 Mar 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15741346 15741346]
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</div>
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<div class="pdbe-citations 1xoy" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: CESG, Center.for.Eukaryotic.Structural.Genomics.]]
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[[Category: Lee MS]]
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[[Category: Lee, M.S.]]
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[[Category: Markley JL]]
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[[Category: Markley, J.L.]]
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[[Category: Robert CT]]
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[[Category: Robert, C.T.]]
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[[Category: Song J]]
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[[Category: Song, J.]]
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[[Category: center for eukaryotic structural genomics]]
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[[Category: cesg]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:14:29 2007''
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Current revision

Solution structure of At3g04780.1, an Arabidopsis ortholog of the C-terminal domain of human thioredoxin-like protein

PDB ID 1xoy

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