This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xsw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:57, 15 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1xsw.png|left|200px]]
 
-
<!--
+
==The solid-state NMR structure of Kaliotoxin==
-
The line below this paragraph, containing "STRUCTURE_1xsw", creates the "Structure Box" on the page.
+
<StructureSection load='1xsw' size='340' side='right'caption='[[1xsw]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1xsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus_mauritanicus Androctonus mauritanicus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSW FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsw OCA], [https://pdbe.org/1xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsw RCSB], [https://www.ebi.ac.uk/pdbsum/1xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsw ProSAT]</span></td></tr>
-
{{STRUCTURE_1xsw| PDB=1xsw | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsw_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xsw ConSurf].
 +
<div style="clear:both"></div>
-
===The solid-state NMR structure of Kaliotoxin===
+
==See Also==
-
 
+
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1XSW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Androctonus_mauretanicus_mauretanicus Androctonus mauretanicus mauretanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSW OCA].
+
[[Category: Androctonus mauritanicus mauritanicus]]
-
 
+
[[Category: Large Structures]]
-
==Reference==
+
[[Category: Baldus M]]
-
A concept for rapid protein-structure determination by solid-state NMR spectroscopy., Lange A, Becker S, Seidel K, Giller K, Pongs O, Baldus M, Angew Chem Int Ed Engl. 2005 Mar 29;44(14):2089-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15744789 15744789]
+
[[Category: Becker S]]
-
[[Category: Androctonus mauretanicus mauretanicus]]
+
[[Category: Giller K]]
-
[[Category: Single protein]]
+
[[Category: Lange A]]
-
[[Category: Baldus, M.]]
+
[[Category: Pongs O]]
-
[[Category: Becker, S.]]
+
[[Category: Seidel K]]
-
[[Category: Giller, K.]]
+
-
[[Category: Lange, A.]]
+
-
[[Category: Pongs, O.]]
+
-
[[Category: Seidel, K.]]
+
-
[[Category: Toxin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:24:05 2008''
+

Current revision

The solid-state NMR structure of Kaliotoxin

PDB ID 1xsw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xsw"
Personal tools