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1xxe

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==RDC refined solution structure of the AaLpxC/TU-514 complex==
==RDC refined solution structure of the AaLpxC/TU-514 complex==
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<StructureSection load='1xxe' size='340' side='right' caption='[[1xxe]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='1xxe' size='340' side='right'caption='[[1xxe]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xxe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzt 1nzt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XXE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xxe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzt 1nzt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TUX:1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL'>TUX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LpxC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TUX:1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL'>TUX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xxe RCSB], [http://www.ebi.ac.uk/pdbsum/1xxe PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxe OCA], [https://pdbe.org/1xxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxe RCSB], [https://www.ebi.ac.uk/pdbsum/1xxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxe ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxe_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxe_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxe ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1xxe" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
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*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase 3D structures|UDP-3-O-acyl-N-acetylglucosamine deacetylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
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[[Category: Coggins, B E.]]
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[[Category: Large Structures]]
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[[Category: Hindsgaul, O.]]
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[[Category: Coggins BE]]
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[[Category: Jiang, L.]]
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[[Category: Hindsgaul O]]
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[[Category: Li, X.]]
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[[Category: Jiang L]]
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[[Category: McClerren, A L.]]
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[[Category: Li X]]
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[[Category: Raetz, C R.H.]]
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[[Category: McClerren AL]]
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[[Category: Rudolph, J.]]
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[[Category: Raetz CRH]]
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[[Category: Zhou, P.]]
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[[Category: Rudolph J]]
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[[Category: Hydrolase]]
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[[Category: Zhou P]]
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[[Category: Lipid some]]
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[[Category: Lipopolysaccharide udp-3-o-acyl-n-acetylglucosamine deacetylase]]
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[[Category: Lp]]
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[[Category: Lpxc]]
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[[Category: Metalloamidase]]
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[[Category: Tu-514]]
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[[Category: Zinc metalloamidase]]
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Current revision

RDC refined solution structure of the AaLpxC/TU-514 complex

PDB ID 1xxe

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