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1yis

From Proteopedia

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[[Image:1yis.gif|left|200px]]
 
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{{Structure
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==Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase==
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|PDB= 1yis |SIZE=350|CAPTION= <scene name='initialview01'>1yis</scene>, resolution 2.40&Aring;
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<StructureSection load='1yis' size='340' side='right'caption='[[1yis]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1yis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIS FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylosuccinate_lyase Adenylosuccinate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.2 4.3.2.2]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yis OCA], [https://pdbe.org/1yis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yis RCSB], [https://www.ebi.ac.uk/pdbsum/1yis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yis ProSAT], [https://www.topsan.org/Proteins/SECSG/1yis TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PUR8_CAEEL PUR8_CAEEL] Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yis_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yis ConSurf].
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<div style="clear:both"></div>
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'''Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase'''
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==See Also==
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*[[Adenylosuccinate lyase 3D structures|Adenylosuccinate lyase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1YIS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIS OCA].
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[[Category: Adenylosuccinate lyase]]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: An, J.]]
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[[Category: An J]]
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[[Category: Arabshahi, A.]]
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[[Category: Arabshahi A]]
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[[Category: Bray, T.]]
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[[Category: Bray T]]
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[[Category: Cao, Z.]]
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[[Category: Cao Z]]
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[[Category: Chen, Y J.]]
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[[Category: Chen Y-J]]
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[[Category: Delucas, L.]]
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[[Category: Delucas L]]
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[[Category: Gray, R.]]
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[[Category: Gray R]]
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[[Category: Huang, W.]]
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[[Category: Huang W]]
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[[Category: Johnson, D.]]
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[[Category: Johnson D]]
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[[Category: Karpova, E.]]
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[[Category: Karpova E]]
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[[Category: Li, S.]]
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[[Category: Li S]]
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[[Category: Lu, S.]]
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[[Category: Lu S]]
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[[Category: Luan, C H.]]
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[[Category: Luan C-H]]
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[[Category: Luo, D.]]
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[[Category: Luo D]]
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[[Category: Luo, M.]]
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[[Category: Luo M]]
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[[Category: McKinstry, A.]]
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[[Category: McKinstry A]]
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[[Category: Qiu, S.]]
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[[Category: Qiu S]]
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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[[Category: Schormann N]]
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[[Category: Schormann, N.]]
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[[Category: Shang Q]]
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[[Category: Shang, Q.]]
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[[Category: Symersky J]]
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[[Category: Symersky, J.]]
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[[Category: Tsao J]]
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[[Category: Tsao, J.]]
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[[Category: Zhang Y]]
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[[Category: Zhang, Y.]]
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[[Category: Zhou J]]
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[[Category: Zhou, J.]]
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[[Category: SO4]]
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[[Category: caenorhabditis; x-ray structure]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: secsg]]
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[[Category: southeast collaboratory for structural genomic]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:23:26 2008''
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Current revision

Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase

PDB ID 1yis

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