This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1yis
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase== | ==Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase== | ||
| - | <StructureSection load='1yis' size='340' side='right' caption='[[1yis]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='1yis' size='340' side='right'caption='[[1yis]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1yis]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1yis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yis OCA], [https://pdbe.org/1yis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yis RCSB], [https://www.ebi.ac.uk/pdbsum/1yis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yis ProSAT], [https://www.topsan.org/Proteins/SECSG/1yis TOPSAN]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PUR8_CAEEL PUR8_CAEEL] Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yis_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yis_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yis ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Adenylosuccinate lyase 3D structures|Adenylosuccinate lyase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Caenorhabditis elegans]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: An | + | [[Category: An J]] |
| - | [[Category: Arabshahi | + | [[Category: Arabshahi A]] |
| - | [[Category: Bray | + | [[Category: Bray T]] |
| - | [[Category: Cao | + | [[Category: Cao Z]] |
| - | [[Category: Chen | + | [[Category: Chen Y-J]] |
| - | [[Category: Delucas | + | [[Category: Delucas L]] |
| - | [[Category: Gray | + | [[Category: Gray R]] |
| - | [[Category: Huang | + | [[Category: Huang W]] |
| - | [[Category: Johnson | + | [[Category: Johnson D]] |
| - | [[Category: Karpova | + | [[Category: Karpova E]] |
| - | [[Category: Li | + | [[Category: Li S]] |
| - | [[Category: Lu | + | [[Category: Lu S]] |
| - | [[Category: Luan | + | [[Category: Luan C-H]] |
| - | [[Category: Luo | + | [[Category: Luo D]] |
| - | [[Category: Luo | + | [[Category: Luo M]] |
| - | [[Category: McKinstry | + | [[Category: McKinstry A]] |
| - | [[Category: Qiu | + | [[Category: Qiu S]] |
| - | + | [[Category: Schormann N]] | |
| - | [[Category: Schormann | + | [[Category: Shang Q]] |
| - | [[Category: Shang | + | [[Category: Symersky J]] |
| - | [[Category: Symersky | + | [[Category: Tsao J]] |
| - | [[Category: Tsao | + | [[Category: Zhang Y]] |
| - | [[Category: Zhang | + | [[Category: Zhou J]] |
| - | [[Category: Zhou | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase
| |||||||||||
Categories: Caenorhabditis elegans | Large Structures | An J | Arabshahi A | Bray T | Cao Z | Chen Y-J | Delucas L | Gray R | Huang W | Johnson D | Karpova E | Li S | Lu S | Luan C-H | Luo D | Luo M | McKinstry A | Qiu S | Schormann N | Shang Q | Symersky J | Tsao J | Zhang Y | Zhou J
