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1yjd

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Current revision (08:03, 15 May 2024) (edit) (undo)
 
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<StructureSection load='1yjd' size='340' side='right'caption='[[1yjd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='1yjd' size='340' side='right'caption='[[1yjd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1yjd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YJD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1yjd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YJD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yjd OCA], [http://pdbe.org/1yjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yjd RCSB], [http://www.ebi.ac.uk/pdbsum/1yjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yjd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yjd OCA], [https://pdbe.org/1yjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yjd RCSB], [https://www.ebi.ac.uk/pdbsum/1yjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yjd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
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[https://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Davis, S J]]
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[[Category: Davis SJ]]
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[[Category: Esnouf, R M]]
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[[Category: Esnouf RM]]
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[[Category: Evans, E J]]
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[[Category: Evans EJ]]
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[[Category: Gilbert, R J.C]]
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[[Category: Gilbert RJC]]
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[[Category: James, J R]]
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[[Category: James JR]]
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[[Category: Manso-Sancho, R]]
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[[Category: Manso-Sancho R]]
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[[Category: Sorensen, P]]
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[[Category: Sorensen P]]
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[[Category: Stuart, D I]]
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[[Category: Stuart DI]]
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[[Category: Cd28 homodimer]]
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[[Category: Igsf]]
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[[Category: Immune system-signaling protein complex]]
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Current revision

Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)

PDB ID 1yjd

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