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1yn6
From Proteopedia
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| - | [[Image:1yn6.gif|left|200px]]<br /><applet load="1yn6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1yn6, resolution 2.2Å" /> | ||
| - | '''Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase'''<br /> | ||
| - | == | + | ==Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase== |
| - | + | <StructureSection load='1yn6' size='340' side='right'caption='[[1yn6]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1yn6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/swine/Iowa/15/1930(H1N1)) Influenza A virus (A/swine/Iowa/15/1930(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn6 OCA], [https://pdbe.org/1yn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn6 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PA_I30A0 PA_I30A0] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.[UniProtKB:P03433] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn6_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn6 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | |
| + | *[[MHC 3D structures|MHC 3D structures]] | ||
| + | *[[MHC I 3D structures|MHC I 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Doherty PC]] | |
| - | + | [[Category: Dunstone MA]] | |
| - | [[Category: Doherty | + | [[Category: Kedzierska K]] |
| - | [[Category: Dunstone | + | [[Category: Komodromou H]] |
| - | [[Category: | + | [[Category: La Gruta NL]] |
| - | [[Category: | + | [[Category: McCluskey J]] |
| - | [[Category: | + | [[Category: Purcell AW]] |
| - | [[Category: McCluskey | + | [[Category: Rossjohn J]] |
| - | [[Category: Purcell | + | [[Category: Turner SJ]] |
| - | [[Category: Rossjohn | + | [[Category: Walden H]] |
| - | [[Category: Turner | + | [[Category: Webb AI]] |
| - | [[Category: Walden | + | [[Category: Webby R]] |
| - | [[Category: Webb | + | [[Category: Xie W]] |
| - | [[Category: Webby | + | |
| - | [[Category: Xie | + | |
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Current revision
Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase
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Categories: Large Structures | Mus musculus | Doherty PC | Dunstone MA | Kedzierska K | Komodromou H | La Gruta NL | McCluskey J | Purcell AW | Rossjohn J | Turner SJ | Walden H | Webb AI | Webby R | Xie W
