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1yn7

From Proteopedia

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[[Image:1yn7.png|left|200px]]
 
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{{STRUCTURE_1yn7| PDB=1yn7 | SCENE= }}
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==Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a mutated peptide (R7A) of the influenza A acid polymerase==
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<StructureSection load='1yn7' size='340' side='right'caption='[[1yn7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a mutated peptide (R7A) of the influenza A acid polymerase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yn7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/swine/Iowa/15/1930(H1N1)) Influenza A virus (A/swine/Iowa/15/1930(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn7 OCA], [https://pdbe.org/1yn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn7 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn7 ProSAT]</span></td></tr>
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[[1yn7]] is a 3 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN7 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn7 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015785764</ref><ref group="xtra">PMID:015735650</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Doherty PC]]
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[[Category: Doherty, P C.]]
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[[Category: Dunstone MA]]
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[[Category: Dunstone, M A.]]
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[[Category: Kedzierska K]]
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[[Category: Gruta, N L.La.]]
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[[Category: Komodromou H]]
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[[Category: Kedzierska, K.]]
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[[Category: La Gruta NL]]
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[[Category: Komodromou, H.]]
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[[Category: McCluskey J]]
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[[Category: McCluskey, J.]]
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[[Category: Purcell AW]]
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[[Category: Purcell, A W.]]
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[[Category: Rossjohn J]]
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[[Category: Rossjohn, J.]]
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[[Category: Turner SJ]]
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[[Category: Turner, S J.]]
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[[Category: Walden H]]
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[[Category: Walden, H.]]
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[[Category: Webb AI]]
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[[Category: Webb, A I.]]
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[[Category: Webby R]]
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[[Category: Webby, R.]]
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[[Category: Xie W]]
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[[Category: Xie, W.]]
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[[Category: H2-db]]
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[[Category: Immune system]]
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[[Category: Influenza some]]
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[[Category: Mhc class 1]]
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[[Category: Peptide of acid polymerase]]
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Current revision

Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a mutated peptide (R7A) of the influenza A acid polymerase

PDB ID 1yn7

Drag the structure with the mouse to rotate

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