This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ysw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:05, 15 May 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand==
==Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand==
-
<StructureSection load='1ysw' size='340' side='right'caption='[[1ysw]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+
<StructureSection load='1ysw' size='340' side='right'caption='[[1ysw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1ysw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YSW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1ysw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSW FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43B:3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE'>43B</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g5m|1g5m]], [[1gjh|1gjh]], [[1ysg|1ysg]], [[1ysi|1ysi]], [[1ysx|1ysx]], [[1ysn|1ysn]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43B:3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE'>43B</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysw OCA], [https://pdbe.org/1ysw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysw RCSB], [https://www.ebi.ac.uk/pdbsum/1ysw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysw ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ysw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysw OCA], [http://pdbe.org/1ysw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ysw RCSB], [http://www.ebi.ac.uk/pdbsum/1ysw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysw ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
+
[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
+
[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 39: Line 38:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Armstrong, R C]]
+
[[Category: Armstrong RC]]
-
[[Category: Augeri, D J]]
+
[[Category: Augeri DJ]]
-
[[Category: Belli, B A]]
+
[[Category: Belli BA]]
-
[[Category: Bruncko, M]]
+
[[Category: Bruncko M]]
-
[[Category: Connor, J M.O]]
+
[[Category: Deckwerth TL]]
-
[[Category: Deckwerth, T L]]
+
[[Category: Dinges J]]
-
[[Category: Dinges, J]]
+
[[Category: Elmore SW]]
-
[[Category: Elmore, S W]]
+
[[Category: Fesik SW]]
-
[[Category: Fesik, S W]]
+
[[Category: Hajduk PJ]]
-
[[Category: Hajduk, P J]]
+
[[Category: Joseph MK]]
-
[[Category: Joseph, M K]]
+
[[Category: Kitada S]]
-
[[Category: Kitada, S]]
+
[[Category: Korsmeyer SJ]]
-
[[Category: Korsmeyer, S J]]
+
[[Category: Kunzer AR]]
-
[[Category: Kunzer, A R]]
+
[[Category: Letai A]]
-
[[Category: Letai, A]]
+
[[Category: Li C]]
-
[[Category: Li, C]]
+
[[Category: Mitten MJ]]
-
[[Category: Mitten, M J]]
+
[[Category: Nettesheim DG]]
-
[[Category: Nettesheim, D G]]
+
[[Category: Ng S]]
-
[[Category: Ng, S]]
+
[[Category: Nimmer PM]]
-
[[Category: Nimmer, P M]]
+
[[Category: O'Connor JM]]
-
[[Category: Oleksijew, A]]
+
[[Category: Oleksijew A]]
-
[[Category: Oltersdorf, T]]
+
[[Category: Oltersdorf T]]
-
[[Category: Petros, A M]]
+
[[Category: Petros AM]]
-
[[Category: Reed, J C]]
+
[[Category: Reed JC]]
-
[[Category: Rosenberg, S H]]
+
[[Category: Rosenberg SH]]
-
[[Category: Shen, W]]
+
[[Category: Shen W]]
-
[[Category: Shoemaker, A R]]
+
[[Category: Shoemaker AR]]
-
[[Category: Tahir, S K]]
+
[[Category: Tahir SK]]
-
[[Category: Thompson, C B]]
+
[[Category: Thompson CB]]
-
[[Category: Tomaselli, K J]]
+
[[Category: Tomaselli KJ]]
-
[[Category: Wang, B]]
+
[[Category: Wang B]]
-
[[Category: Wendt, M D]]
+
[[Category: Wendt MD]]
-
[[Category: Zhang, H]]
+
[[Category: Zhang H]]
-
[[Category: Apoptosis]]
+
-
[[Category: Complex]]
+

Current revision

Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand

PDB ID 1ysw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ysw"
Personal tools