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1z4k
From Proteopedia
(Difference between revisions)
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<StructureSection load='1z4k' size='340' side='right'caption='[[1z4k]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='1z4k' size='340' side='right'caption='[[1z4k]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1z4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1z4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4K FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T3P:THYMIDINE-3-PHOSPHATE'>T3P</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4k OCA], [https://pdbe.org/1z4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4k RCSB], [https://www.ebi.ac.uk/pdbsum/1z4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4k ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4k OCA], [https://pdbe.org/1z4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4k RCSB], [https://www.ebi.ac.uk/pdbsum/1z4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bianchi | + | [[Category: Bianchi V]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Rinaldo-Matthis | + | [[Category: Rinaldo-Matthis A]] |
| - | [[Category: Ruzzenente | + | [[Category: Ruzzenente B]] |
| - | [[Category: Wallden | + | [[Category: Wallden K]] |
| - | + | ||
| - | + | ||
Current revision
Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 3'-monophosphate
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