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1zs5

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[[Image:1zs5.gif|left|200px]]
 
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{{Structure
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==Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association==
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|PDB= 1zs5 |SIZE=350|CAPTION= <scene name='initialview01'>1zs5</scene>
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<StructureSection load='1zs5' size='340' side='right'caption='[[1zs5]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MIB:(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE'>MIB</scene>
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<table><tr><td colspan='2'>[[1zs5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZS5 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= PCAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MIB:(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE'>MIB</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs5 OCA], [https://pdbe.org/1zs5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zs5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zs5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zs5 ConSurf].
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<div style="clear:both"></div>
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'''Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association'''
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1ZS5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS5 OCA].
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__TOC__
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[[Category: Histone acetyltransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Godbole, S.]]
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[[Category: Godbole S]]
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[[Category: Muller, M.]]
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[[Category: Muller M]]
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[[Category: Sanchez, R.]]
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[[Category: Sanchez R]]
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[[Category: Yan, S.]]
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[[Category: Yan S]]
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[[Category: Zeng, L.]]
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[[Category: Zeng L]]
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[[Category: Zhou, M.]]
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[[Category: Zhou M]]
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[[Category: MIB]]
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[[Category: bromodomain]]
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[[Category: histone-acetyltransferase]]
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[[Category: nmr-structure chemical ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:39:12 2008''
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Current revision

Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association

PDB ID 1zs5

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