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2a4v
From Proteopedia
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==Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidase== | ==Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidase== | ||
| - | <StructureSection load='2a4v' size='340' side='right' caption='[[2a4v]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='2a4v' size='340' side='right'caption='[[2a4v]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2a4v]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2a4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4V FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4v OCA], [https://pdbe.org/2a4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4v RCSB], [https://www.ebi.ac.uk/pdbsum/2a4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4v ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/DOT5_YEAST DOT5_YEAST] Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen preoxide. Acts as an antioxidant necessary for stationary phase survival.<ref>PMID:9755194</ref> <ref>PMID:12730197</ref> <ref>PMID:12925864</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4v_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4v_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a4v ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Cha | + | [[Category: Cha M-K]] |
| - | [[Category: Choi | + | [[Category: Choi J]] |
| - | [[Category: Choi | + | [[Category: Choi S]] |
| - | [[Category: Chon | + | [[Category: Chon J-K]] |
| - | [[Category: Kim | + | [[Category: Kim I-H]] |
| - | [[Category: Shin | + | [[Category: Shin W]] |
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Current revision
Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidase
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Categories: Large Structures | Saccharomyces cerevisiae | Cha M-K | Choi J | Choi S | Chon J-K | Kim I-H | Shin W
