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2a4v

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[[Image:2a4v.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidase==
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|PDB= 2a4v |SIZE=350|CAPTION= <scene name='initialview01'>2a4v</scene>, resolution 1.800&Aring;
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<StructureSection load='2a4v' size='340' side='right'caption='[[2a4v]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2a4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4V FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= DOT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4v OCA], [https://pdbe.org/2a4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4v RCSB], [https://www.ebi.ac.uk/pdbsum/2a4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4v ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4v OCA], [http://www.ebi.ac.uk/pdbsum/2a4v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a4v RCSB]</span>
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[https://www.uniprot.org/uniprot/DOT5_YEAST DOT5_YEAST] Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen preoxide. Acts as an antioxidant necessary for stationary phase survival.<ref>PMID:9755194</ref> <ref>PMID:12730197</ref> <ref>PMID:12925864</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a4v ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidase'''
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==See Also==
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2A4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4V OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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Crystal structure of the C107S/C112S mutant of yeast nuclear 2-Cys peroxiredoxin., Choi J, Choi S, Chon JK, Choi J, Cha MK, Kim IH, Shin W, Proteins. 2005 Dec 1;61(4):1146-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16245326 16245326]
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[[Category: Peroxiredoxin]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Cha M-K]]
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[[Category: Cha, M K.]]
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[[Category: Choi J]]
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[[Category: Choi, J.]]
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[[Category: Choi S]]
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[[Category: Choi, S.]]
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[[Category: Chon J-K]]
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[[Category: Chon, J K.]]
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[[Category: Kim I-H]]
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[[Category: Kim, I H.]]
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[[Category: Shin W]]
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[[Category: Shin, W.]]
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[[Category: atypical 2-cys peroxiredoxin]]
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[[Category: yeast nuclear thiol peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:47:51 2008''
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Current revision

Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidase

PDB ID 2a4v

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