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2aaz

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{{Large structure}}
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==Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate==
==Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate==
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<StructureSection load='2aaz' size='340' side='right' caption='[[2aaz]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='2aaz' size='340' side='right'caption='[[2aaz]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2aaz]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_32045 Atcc 32045]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AAZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2aaz]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans Cryptococcus neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AAZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a9w|2a9w]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TMP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5207 ATCC 32045])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aaz OCA], [https://pdbe.org/2aaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aaz RCSB], [https://www.ebi.ac.uk/pdbsum/2aaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aaz ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aaz OCA], [http://pdbe.org/2aaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aaz RCSB], [http://www.ebi.ac.uk/pdbsum/2aaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aaz ProSAT]</span></td></tr>
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</table>
</table>
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{{Large structure}}
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_CRYNJ TYSY_CRYNJ]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2aaz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2aaz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 32045]]
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[[Category: Cryptococcus neoformans]]
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[[Category: Thymidylate synthase]]
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[[Category: Large Structures]]
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[[Category: Anderson, A C]]
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[[Category: Anderson AC]]
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[[Category: Costi, M P]]
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[[Category: Costi MP]]
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[[Category: Ferrari, S]]
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[[Category: Ferrari S]]
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[[Category: Finer-Moore, J S]]
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[[Category: Finer-Moore JS]]
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[[Category: Krucinski, J]]
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[[Category: Krucinski J]]
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[[Category: Neil, R H.O]]
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[[Category: O'Neil RH]]
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[[Category: Stroud, R M]]
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[[Category: Stroud RM]]
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[[Category: Methyl transferase]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Transferase]]
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Current revision

Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate

PDB ID 2aaz

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