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2ah2

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Current revision (08:17, 15 May 2024) (edit) (undo)
 
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<StructureSection load='2ah2' size='340' side='right'caption='[[2ah2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2ah2' size='340' side='right'caption='[[2ah2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ah2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s0k 1s0k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AH2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ah2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s0k 1s0k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AH2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FSI:5-(ACETYLAMINO)-3,5-DIDEOXY-3-FLUORO-D-ERYTHRO-ALPHA-L-MANNO-NON-2-ULOPYRANOSONIC+ACID'>FSI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ags|2ags]], [[2a75|2a75]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FSI:5-(ACETYLAMINO)-3,5-DIDEOXY-3-FLUORO-D-ERYTHRO-ALPHA-L-MANNO-NON-2-ULOPYRANOSONIC+ACID'>FSI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ah2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ah2 OCA], [https://pdbe.org/2ah2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ah2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ah2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ah2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ah2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ah2 OCA], [https://pdbe.org/2ah2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ah2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ah2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ah2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q26966_TRYCR Q26966_TRYCR]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycr]]
 
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[[Category: Alzari, P M]]
 
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[[Category: Amaya, M F]]
 
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[[Category: Buschiazzo, A]]
 
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[[Category: Damager, I]]
 
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[[Category: Frasch, A C]]
 
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[[Category: Nguyen, T]]
 
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[[Category: Paris, G]]
 
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[[Category: Watts, A G]]
 
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[[Category: Wehenkel, A]]
 
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[[Category: Withers, S G]]
 
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[[Category: Covalent intermediate]]
 
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[[Category: Hydrolase]]
 
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[[Category: Sialic acid]]
 
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[[Category: Transglycosidase]]
 
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Alzari PM]]
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[[Category: Amaya MF]]
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[[Category: Buschiazzo A]]
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[[Category: Damager I]]
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[[Category: Frasch AC]]
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[[Category: Nguyen T]]
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[[Category: Paris G]]
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[[Category: Watts AG]]
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[[Category: Wehenkel A]]
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[[Category: Withers SG]]

Current revision

Trypanosoma cruzi trans-sialidase in complex with 2,3-difluorosialic acid (covalent intermediate)

PDB ID 2ah2

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