This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Activin
From Proteopedia
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='5hlz' size='340' side='right' caption='Human activin A pro domain (grey, pink) and mature domain (green, yellow) (PDB code [[5hlz]])' scene=''> | |
| - | <StructureSection load='5hlz' size='340' side='right' caption='Human activin A (PDB code [[5hlz]])' scene=''> | + | |
== Function == | == Function == | ||
| - | '''Activin A''' or '''inhibitin β chain A''' (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner<ref>PMID: | + | '''Activin A''' or '''inhibitin β chain A''' (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner<ref>PMID:16140969</ref>. |
| + | |||
| + | See also [[TGF beta signaling pathway]]. | ||
== Relevance == | == Relevance == | ||
| Line 24: | Line 25: | ||
[[2b0u]], [[2arp]], [[2p6a]] - hActA mature domain + follistatin<br /> | [[2b0u]], [[2arp]], [[2p6a]] - hActA mature domain + follistatin<br /> | ||
[[3b4v]] - hActA mature domain + follistatin-like 3<br /> | [[3b4v]] - hActA mature domain + follistatin-like 3<br /> | ||
| + | [[6y6n]], [[6y6o]] - hActA mature domain + diazepine derivative<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of activin A
Updated on 21-May-2024
5hlz, 5hly - hActA - human
2arv - hActA mature domain residues 311-426
1nys, 1nyu, 1s4y - hActA mature domain + Acvr2B LBD
2b0u, 2arp, 2p6a - hActA mature domain + follistatin
3b4v - hActA mature domain + follistatin-like 3
6y6n, 6y6o - hActA mature domain + diazepine derivative
References
- ↑ Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res. 2005 Sep 1;65(17):7968-75. doi: 10.1158/0008-5472.CAN-04-3553. PMID:16140969 doi:http://dx.doi.org/10.1158/0008-5472.CAN-04-3553
- ↑ Hubner G, Brauchle M, Gregor M, Werner S. Activin A: a novel player and inflammatory marker in inflammatory bowel disease? Lab Invest. 1997 Oct;77(4):311-8. PMID:9354766
- ↑ Wang X, Fischer G, Hyvonen M. Structure and activation of pro-activin A. Nat Commun. 2016 Jul 4;7:12052. doi: 10.1038/ncomms12052. PMID:27373274 doi:http://dx.doi.org/10.1038/ncomms12052
