Aerolysin
From Proteopedia
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<StructureSection load='1pre' size='340' side='right' caption='Proaerolysin dimer (PDB code [[1pre]]).' scene='43/430021/Cv/2'> | <StructureSection load='1pre' size='340' side='right' caption='Proaerolysin dimer (PDB code [[1pre]]).' scene='43/430021/Cv/2'> | ||
| - | [[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer.<ref>PMID:7510043</ref> For toxins in Proteopedia see [[Toxins]]. | + | [[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor '''proaerolysin''' (proAer) which gets cleaved at Arg-432 by furin to produce the active Aer.<ref>PMID:7510043</ref> For toxins in Proteopedia see [[Toxins]]. |
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References
- ↑ Parker MW, Buckley JT, Postma JP, Tucker AD, Leonard K, Pattus F, Tsernoglou D. Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Nature. 1994 Jan 20;367(6460):292-5. PMID:7510043 doi:http://dx.doi.org/10.1038/367292a0
