A-kinase anchor protein
From Proteopedia
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'''A-kinase anchor proteins''' (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them <ref>PMID:10712918</ref>. | '''A-kinase anchor proteins''' (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them <ref>PMID:10712918</ref>. | ||
AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia<ref>PMID:17566268</ref>. '''A-kinase anchor protein 10''' is also named '''dual specificity A-kinase anchor protein 2'''. | AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia<ref>PMID:17566268</ref>. '''A-kinase anchor protein 10''' is also named '''dual specificity A-kinase anchor protein 2'''. | ||
| + | *'''Small membrane A-kinase anchor protein''' (smAKAP) is localised at the plasma membrane<ref>PMID:23115245</ref>. | ||
== Relevance == | == Relevance == | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of A-kinase anchor protein == | ||
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| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *A-kinase anchor protein 10 | ||
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| - | **[[3tmh]] – hAKAP10 A-kinase-binding domain + cAMP-dependent protein kinase type II-α regulatory subunit + NHERF-3 <br /> | ||
| - | **[[3im4]] – hAKAP10 A-kinase-binding domain + cAMP-dependent protein kinase type II-alpha regulatory subunit<br /> | ||
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| - | *A-kinase anchor protein 13 | ||
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| - | **[[4d0o]] – hAKAP13 DH domain – human <br /> | ||
| - | **[[4d0n]] – hAKAP13 DH domain + RhoA<br /> | ||
| - | **[[2lg1]] – hAKAP13 PH domain - NMR<br /> | ||
| - | **[[6bca]] – hAKAP13 PH domain + RhoA + GTP analog<br /> | ||
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| - | *A-kinase anchor protein 18 | ||
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| - | **[[5jj2]] – hAKAP18 2H phosphoestease domain <br /> | ||
| - | **[[2vfl]] – hAKAP18 2H phosphoestease domain + CMP<br /> | ||
| - | **[[3j4q]], [[3j4r]] – hAKAP18 residues 1-353 + cAMP-dependent protein kinase type II-α regulatory subunit + PKA C-alpha – Cryo EM <br /> | ||
| - | **[[4zp3]] – hAKAP18 residues 43-82 + cAMP-dependent protein kinase type II-α regulatory subunit <br /> | ||
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| - | *Small membrane A-kinase anchor protein | ||
| - | **[[5hvz]] – hsmAKAP A-kinase-binding domain + cAMP-dependent protein kinase type II-α regulatory subunit <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Edwards AS, Scott JD. A-kinase anchoring proteins: protein kinase A and beyond. Curr Opin Cell Biol. 2000 Apr;12(2):217-21. PMID:10712918
- ↑ Carr DW, Newell AE. The role of A-kinase anchoring proteins (AKaps) in regulating sperm function. Soc Reprod Fertil Suppl. 2007;63:135-41. PMID:17566268
- ↑ Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21;287(52):43789-97. doi: 10.1074/jbc.M112.395970. Epub, 2012 Oct 31. PMID:23115245 doi:http://dx.doi.org/10.1074/jbc.M112.395970
- ↑ Diviani D, Dodge-Kafka KL, Li J, Kapiloff MS. A-kinase anchoring proteins: scaffolding proteins in the heart. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1742-53. doi:, 10.1152/ajpheart.00569.2011. Epub 2011 Aug 19. PMID:21856912 doi:http://dx.doi.org/10.1152/ajpheart.00569.2011
- ↑ Gotz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zuhlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J. 2016 Apr 21. pii: BCJ20160242. PMID:27102985 doi:http://dx.doi.org/10.1042/BCJ20160242
