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9bkk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex== |
| - | + | <StructureSection load='9bkk' size='340' side='right'caption='[[9bkk]], [[Resolution|resolution]] 2.51Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9bkk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BKK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.51Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bkk OCA], [https://pdbe.org/9bkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bkk RCSB], [https://www.ebi.ac.uk/pdbsum/9bkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bkk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GNAS1_HUMAN GNAS1_HUMAN] The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAS1_HUMAN GNAS1_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).[UniProtKB:Q6R0H7] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Belousoff MJ]] | ||
| + | [[Category: Cary BP]] | ||
| + | [[Category: Christopoulos A]] | ||
| + | [[Category: Desai AJ]] | ||
| + | [[Category: Furness SGB]] | ||
| + | [[Category: Harikumar KG]] | ||
| + | [[Category: Miller LJ]] | ||
| + | [[Category: Mobbs JI]] | ||
| + | [[Category: Sexton PM]] | ||
| + | [[Category: Toufaily C]] | ||
| + | [[Category: Wootten D]] | ||
| + | [[Category: Xu X]] | ||
| + | [[Category: Zhao P]] | ||
Current revision
Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex
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Categories: Homo sapiens | Large Structures | Belousoff MJ | Cary BP | Christopoulos A | Desai AJ | Furness SGB | Harikumar KG | Miller LJ | Mobbs JI | Sexton PM | Toufaily C | Wootten D | Xu X | Zhao P
