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1bj8

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==THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE==
==THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE==
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<StructureSection load='1bj8' size='340' side='right' caption='[[1bj8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='1bj8' size='340' side='right'caption='[[1bj8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1bj8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1bj8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ8 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj8 OCA], [http://pdbe.org/1bj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bj8 RCSB], [http://www.ebi.ac.uk/pdbsum/1bj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj8 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj8 OCA], [https://pdbe.org/1bj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN]] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
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[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dijkstra, K]]
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[[Category: Large Structures]]
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[[Category: Grotzinger, J]]
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[[Category: Dijkstra K]]
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[[Category: Grzesiek, S]]
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[[Category: Grotzinger J]]
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[[Category: Heinrich, P C]]
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[[Category: Grzesiek S]]
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[[Category: Kernebeck, T]]
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[[Category: Heinrich PC]]
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[[Category: Kurapkat, G]]
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[[Category: Kernebeck T]]
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[[Category: Muller-Newen, G]]
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[[Category: Kurapkat G]]
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[[Category: Pflanz, S]]
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[[Category: Muller-Newen G]]
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[[Category: Scheek, R M]]
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[[Category: Pflanz S]]
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[[Category: Wollmer, A]]
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[[Category: Scheek RM]]
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[[Category: Glycoprotein]]
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[[Category: Wollmer A]]
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[[Category: Receptor]]
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[[Category: Signal transducer of il-6 type cytokine]]
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[[Category: Third n-terminal domain]]
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[[Category: Transmembrane]]
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Current revision

THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1bj8

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