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1du6

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==SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN==
==SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN==
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<StructureSection load='1du6' size='340' side='right'caption='[[1du6]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
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<StructureSection load='1du6' size='340' side='right'caption='[[1du6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1du6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DU6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1du6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DU6 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PBX1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1du6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1du6 OCA], [https://pdbe.org/1du6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1du6 RCSB], [https://www.ebi.ac.uk/pdbsum/1du6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1du6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1du6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1du6 OCA], [https://pdbe.org/1du6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1du6 RCSB], [https://www.ebi.ac.uk/pdbsum/1du6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1du6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PBX1_MOUSE PBX1_MOUSE]] Plays a role in the cAMP-dependent regulation of CYP17 gene expression via its cAMP-regulatory sequence (CRS1) 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4.
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[https://www.uniprot.org/uniprot/PBX1_MOUSE PBX1_MOUSE] Plays a role in the cAMP-dependent regulation of CYP17 gene expression via its cAMP-regulatory sequence (CRS1) 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Featherstone, M]]
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[[Category: Featherstone M]]
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[[Category: Gehring, K]]
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[[Category: Gehring K]]
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[[Category: Green, N]]
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[[Category: Green N]]
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[[Category: Sprules, T]]
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[[Category: Sprules T]]
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[[Category: Gene regulation]]
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[[Category: Homeodomain]]
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Current revision

SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN

PDB ID 1du6

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