1ef5

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[[Image:1ef5.jpg|left|200px]]
 
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{{Structure
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==SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL==
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|PDB= 1ef5 |SIZE=350|CAPTION= <scene name='initialview01'>1ef5</scene>
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<StructureSection load='1ef5' size='340' side='right'caption='[[1ef5]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ef5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EF5 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ef5 OCA], [https://pdbe.org/1ef5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ef5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ef5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ef5 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ef5 TOPSAN]</span></td></tr>
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}}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL'''
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[https://www.uniprot.org/uniprot/RGL1_MOUSE RGL1_MOUSE] Probable guanine nucleotide exchange factor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/1ef5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ef5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.
The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.
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==About this Structure==
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Solution structure of the Ras-binding domain of RGL.,Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:9891982<ref>PMID:9891982</ref>
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1EF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of the Ras-binding domain of RGL., Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S, FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9891982 9891982]
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</div>
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<div class="pdbe-citations 1ef5" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Endo M]]
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[[Category: Endo, M.]]
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[[Category: Ito Y]]
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[[Category: Ito, Y.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Kikuchi A]]
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[[Category: Kikuchi, A.]]
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[[Category: Shirouzu M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Shirouzu, M.]]
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[[Category: Yokoyama, S.]]
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[[Category: ra]]
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[[Category: ra]]
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[[Category: ras-binding domain]]
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[[Category: rbd]]
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[[Category: rgl]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:54:47 2008''
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Current revision

SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL

PDB ID 1ef5

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