1ggq

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{{STRUCTURE_1ggq| PDB=1ggq | SCENE= }}
 
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===OUTER SURFACE PROTEIN C (OSPC) OF BORRELIA BURGDORFERI STRAIN B31===
 
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{{ABSTRACT_PUBMED_11230121}}
 
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==About this Structure==
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==OUTER SURFACE PROTEIN C (OSPC) OF BORRELIA BURGDORFERI STRAIN B31==
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[[1ggq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GGQ OCA].
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<StructureSection load='1ggq' size='340' side='right'caption='[[1ggq]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ggq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_B31 Borreliella burgdorferi B31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GGQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ggq OCA], [https://pdbe.org/1ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ggq RCSB], [https://www.ebi.ac.uk/pdbsum/1ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ggq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OSPC_BORBU OSPC_BORBU] Not known; major immunodominant protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/1ggq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ggq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly beta-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.
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Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.,Kumaran D, Eswaramoorthy S, Luft BJ, Koide S, Dunn JJ, Lawson CL, Swaminathan S EMBO J. 2001 Mar 1;20(5):971-8. PMID:11230121<ref>PMID:11230121</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ggq" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[OspC and Binding|OspC and Binding]]
 
*[[Outer surface protein|Outer surface protein]]
*[[Outer surface protein|Outer surface protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011230121</ref><references group="xtra"/>
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__TOC__
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[[Category: Borrelia burgdorferi]]
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</StructureSection>
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[[Category: Dunn, J J.]]
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[[Category: Borreliella burgdorferi B31]]
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[[Category: Lawson, C L.]]
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[[Category: Large Structures]]
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[[Category: Helical bundle]]
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[[Category: Dunn JJ]]
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[[Category: Homodimer]]
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[[Category: Lawson CL]]
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[[Category: Lyme disease antigen]]
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[[Category: Membrane protein]]
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Current revision

OUTER SURFACE PROTEIN C (OSPC) OF BORRELIA BURGDORFERI STRAIN B31

PDB ID 1ggq

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