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1k3k

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Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus

Structural highlights

1k3k is a 1 chain structure with sequence from Human gammaherpesvirus 8. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q76RI8_HHV8

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.,Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET. Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405 doi:10.1073/pnas.062525799

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k3k"

@@ Line 1: / Line 1: @@
 ==Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus==
-<StructureSection load='1k3k' size='340' side='right' caption='[[1k3k]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1k3k' size='340' side='right'caption='[[1k3k]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1k3k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K3K FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1k3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K3K FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3k OCA], [http://pdbe.org/1k3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k3k RCSB], [http://www.ebi.ac.uk/pdbsum/1k3k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k3k ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3k OCA], [https://pdbe.org/1k3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k3k RCSB], [https://www.ebi.ac.uk/pdbsum/1k3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k3k ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q76RI8_HHV8 Q76RI8_HHV8]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Hhv-8]]
+[[Category: Human gammaherpesvirus 8]]
-[[Category: Fesik, S W]]
+[[Category: Large Structures]]
-[[Category: Huang, Q]]
+[[Category: Fesik SW]]
-[[Category: Olejniczak, E T]]
+[[Category: Huang Q]]
-[[Category: Petros, A M]]
+[[Category: Olejniczak ET]]
-[[Category: Virgin, H W]]
+[[Category: Petros AM]]
-[[Category: Apoptosis]]
+[[Category: Virgin HW]]
-[[Category: Bcl-2]]
-[[Category: Herpesvirus]]
-[[Category: Solution structure]]

1k3k

From Proteopedia

Current revision

Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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