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1m62

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==Solution structure of the BAG domain from BAG4/SODD==
==Solution structure of the BAG domain from BAG4/SODD==
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<StructureSection load='1m62' size='340' side='right' caption='[[1m62]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='1m62' size='340' side='right'caption='[[1m62]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1m62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M62 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1m62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M62 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1i6z|1i6z]], [[1hx1|1hx1]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAG4/SODD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m62 OCA], [https://pdbe.org/1m62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m62 RCSB], [https://www.ebi.ac.uk/pdbsum/1m62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m62 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m62 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m62 RCSB], [http://www.ebi.ac.uk/pdbsum/1m62 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAG4_HUMAN BAG4_HUMAN] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m62_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m62_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m62 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1m62" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[BAG protein|BAG protein]]
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*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Baker, K.]]
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[[Category: Large Structures]]
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[[Category: Briknarova, K.]]
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[[Category: Baker K]]
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[[Category: Cabezas, E.]]
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[[Category: Briknarova K]]
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[[Category: Ely, K R.]]
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[[Category: Cabezas E]]
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[[Category: Homma, S.]]
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[[Category: Ely KR]]
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[[Category: Hoyt, D W.]]
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[[Category: Homma S]]
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[[Category: Li, Z.]]
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[[Category: Hoyt DW]]
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[[Category: Satterthwait, A C.]]
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[[Category: Li Z]]
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[[Category: Takayama, S.]]
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[[Category: Satterthwait AC]]
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[[Category: Bag domain]]
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[[Category: Takayama S]]
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[[Category: Bag4]]
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[[Category: Chaperone]]
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[[Category: Hsp70/hsc70 co-chaperone]]
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[[Category: Silencer of death domain]]
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[[Category: Sodd]]
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Current revision

Solution structure of the BAG domain from BAG4/SODD

PDB ID 1m62

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